Diffraction based biosensors pass light through an analyte sample in order to generate and analyze the corresponding diffraction pattern. Kimberly-Clark's innovations to this platform include diffraction enhancing elements to improve sensitivity and photolithographic printing for improved reliability.
This technology uses an immunoassay sandwich technique to produce an optical diffraction pattern. Antibodies specific to an analyte are bound to the surface of microparticles. Complementary antibodies are bound to the sensor surface in a specified pattern. An analyte binds to antibodies that are bound to the surface of the sensor and to those bound to the microparticles, thereby immobilizing the microparticles in a repeating pattern to the surface of the sensor. Light illuminates the diffraction pattern when transmitted through or reflected by the sensor film.
The photolithography method is a combination of dry and hard contact lithography that uses monochromatic light to modify the sensor surface through a photomask. This method allows for a very precise and accurate patterning of the sensor with a high degree of reproducibility.
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